John Guidetti Manchester City striker John Guidetti has revealed a host of European clubs were chasing his signature this summer before he finally opted to join Celtic.The Sweden international joined the Scottish champions on a season-long loan during the summer transfer window.However the 22-year-old, who was loaned to Stoke last season, confessed that he had plenty of offers on the table.“Clubs such as Olympiacos, AIK and Ajax wanted me, as well as Fiorentina and Palermo,” Guidetti told Heja Sverige.“Some important clubs were after my signature, but I am happy to be at Celtic now.” 1
As reported here numerous times (e.g., 06/14/2004, 12/04/2003, 04/14/2003, 03/28/2003, 02/25/2003, 12/17/2002, 09/26/2002, 03/26/2002, 02/01/2002, 12/06/2001, 08/17/2001, 06/19/2001, 02/21/2001), cells have an elaborate interstate highway system with molecular trucks hauling cargo back and forth. Scientists have known that the cellular highways have polarities labeled plus and minus, and that molecular motors typically go one way. Some motors, like kinesin, drive only in the plus direction, while others, like dynein, go in the minus direction. Now, it is becoming apparent that most pieces of cargo have at least one of each kind of motor, with a stickshift that allows it to drive in forward or reverse. The state of our knowledge about bidirectional transport is explored by Michael Welte in the July 13 issue of Current Biology.1 Welte examines the evidence that many, maybe all, moving cargoes have bidirectional ability. In the microscope, certain organelles like mitochondria and melanosomes are seen to move back and forth rapidly, eventually making it to their target. Why is this, and how is it done? Does the organelle grab motors out of the cytoplasm? Are both motors working in a tug-o’war? Welte cites evidence against these possibilities, and suggests (although hard evidence needs to be found), that the cargo carries both motors, and a “complex coordination machinery … ensures that when one motor is actively engaged with the microtubule, the other motor is turned off.” Moreover, this coordination machinery, whatever it is, may be under the influence of regulatory enzymes. “If the coordination machinery can attach to cargo independent of the motors,” he surmises, “distinct variants of the coordination machinery could be targeted to different cargoes, thus allowing cargo-specific coordination and regulation.” It seems odd, though, that cargoes would undergo a back-and-forth random walk instead of making a beeline to the target. Welte figures there must be biological justification for this behavior, so he examines some possibilities:Economy: “If cargoes always carry motors for both directions, net transport can easily be adjusted or even reversed by simply tweaking the relative activity of the two motors. This is likely to be much quicker than assembling a new set of motors on a cargo, and also allows transport to be abruptly altered depending on cellular needs. It even makes it possible to tune the overall speed of transport by altering the relative contribution of trips in the non-dominant direction.”Setting Up Polarized Distributions: “Sometimes it is necessary to set up a distribution rather than to confine the organelles to a single point …. Even if cargoes accumulate at a certain point (e.g. near plus-ends when motion is biased in the plus-end direction), trips in the non-dominant direction will tend to spread the cargoes out along the tracks, away from the point of accumulation. Modeling shows that by altering the relative contributions of plus- and minus-end trips, a wide range of steep to flat steady-state distributions can be achieved.”Avoiding Obstacles and Exploring Space: “As cytoplasmic dynein often steps sidewise to adjacent proto-filaments, a bidirectional cargo could find itself on the opposite side of the microtubule even after a short minus-end excursion. If it now switches back to kinesin I, it can pass the obstacle. Bidirectionally moving cargoes should, therefore, be less likely to contribute to disastrous traffic jams …. The random walk of bidirectional cargoes allows a single cargo to explore a large region of cellular space, especially if tracks are disordered.”Error Correction: “During unidirectional transport, the critical event that determines directionality of motion is the attachment to either a plus- or minus-end motor. A wrong attachment will cause misdelivery of the cargo. During bidirectional transport, the net direction of transport is determined by the balance of plus- and minus-end trips and can, therefore, be continually evaluated and even altered if physiological conditions change. Thus, bidirectional transport may facilitate error correction.It must be remembered that these motors are operating in the dark without eyes, like automated railroad cars. They don’t have sentient drivers on radios, but rather respond to chemical signals in the environment. Apparently these behaviors achieve the best solution to many complex problems. “Bidirectional transport by opposite-polarity microtubule motors is just one example of multiple motors working together to achieve carefully choreographed transport,” Welte says, as he concludes with a list of open problems needing further elucidation.1Michael A. Welte, “Bidirectional Transport along Microtubules,” Current Biology, Volume 14, Issue 13, 13 July 2004, Pages R525-R537, http://dx.doi.org/10.1016/j.cub.2004.06.045.Think of a 12-year-old kid on motorized rollerblades, one foot going forward, the other reverse. Imagine the tricks he could accomplish (with a little practice) switching from one foot to the other (or the bloody knees as he experiments the first time). Now make the wheels run on monorails. Imagine a complex tangle of rails, some blue, some red, going off in all directions, more dizzying than an amusement park roller coaster. The kid is supposed to put the left foot on the red rails and the right foot on the blue rails (one foot at a time, of course). Now hand him a package to deliver, and put a thousand other kids on the system going in all directions with packages of their own. The rails are also in constant motion, some growing and some shrinking. If the mental picture is becoming too complicated to dwell on further, just realize that something like this is happening in every cell of your body right now. This intracellular transport system is only a small part of a miniaturized city with many other vital tasks being performed flawlessly. The transportation system alone has a large infrastructure of support services. There are linemen for the monorails, pit crewmen for motor repair, traffic cops, construction crews, shippers, receivers and much more, without even considering what the cargoes are and what they do when they arrive. The interior of a cell is a whirlwind of constant activity, all necessary just to sustain life. Rocks do not do this. Evolutionists may jawbone about these systems emerging from chance and natural selection over millions of years of purposeless motion, but the more we can exhibit the details of cellular perfection, the less plausible their story is going to seem to any rational observer. This system is crying out for visualization. The wonder of intracellular transport would come alive if magnified a million times.2(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0
(Visited 48 times, 1 visits today)FacebookTwitterPinterestSave分享0 A well-crafted spear point for a javelin is dated way too early for the current evolutionary timeline.National Geographic announced the find in Ethiopia with a picture of a nicely carved spear point dated at 280,000 years in the evolutionary scheme. That’s 200,000 years older than the date they were thought to first be made by modern humans. According to the standard story, modern humans were not even around that long ago.These javelins are some 200,000 years older than previous examples of similar weapons, suggesting that modern humans and their extinct relatives had the know-how to create these sorts of complex thrown projectiles much earlier than often thought….The oldest artifacts at the site are roughly 279,000 years old. In comparison, the earliest known fossils of Homo sapiens, previously discovered at sites elsewhere in Ethiopia, are about 200,000 years old.The spear point shown is not an isolated artifact. The research team from UC Berkeley found 141 such implements. Human ancestors of that age were only thought to be capable of thrusting and clubbing. By analyzing cracks in the obsidian, researchers were able to infer that the spear points were thrown at the maximum speed possible. “Such weapons are considered signs of complex behavior and were pivotal to the spread of modern humans.”To rescue the evolutionary story, paleoanthropologists are having to posit that “certain behavioral traits that are considered complex and mostly only the domains of anatomically modern humans—such as the capacity to make and use projectiles … had earlier roots and were present in populations ancestral to Homo sapiens.” Yet this pushes the evolution of complex brains able to design, make, test and use these weapons effectively further back as well – leaving little more for evolution to do for nearly 300,000 years. If these people were that smart, what kept them from getting civilized for so long?Evolutionists are wondering who the designers were – Homo heidelbergensis, perhaps? Onlooker John Shea suggested the technology might go even farther back. “This is just the oldest example we have so far of this technology—it doesn’t mean that this is where it first evolved.” There’s a conundrum: the evolution of intelligent design.Paleoanthropology has more falsifications than you can shake a spear at. Next they’ll be discovering the Heidelberg Man version of Shakespeare. That will be the new script: baby pigs evolved into Hamlet. They should be shuddering at this midsummer dream’s nightmare. (It is midsummer in Africa, you know, but a winter’s tale up north.) Instead, they think all’s well that ends badly, and any criticisms are much ado about nothing. But what could be king-lear than admitting you’re wrong? As you like it, they’d rather engage in the shaming of the true than admit their comedy of errors. A tempest in a teapot, they respond dismissively, as if sneezing off their critics. But to sneeze or not to sneeze, that is congestion. Having taken our pound of flesh, measure for measure, we’ll require no further pun-itive damages. Happy Thanksgiving, Americans! Go comet-watching this weekend. Is there ice on ISON?
Share Facebook Twitter Google + LinkedIn Pinterest By Charles Johnson Progressive Farmer Contributing EditorStep into this field outside Herndon, Kentucky, and touch a bit of agricultural history. One year, it may be planted in soybeans, the next year in corn. One thing, though, is certain: It will always be no-tilled.It’s been that way since 1962, when it was among the nation’s first commercial farm fields planted in that then-controversial way. Harry Young Jr., an innovative farmer looking for ways to farm more efficiently, cobbled together a no-till planter out of an Allis-Chalmers two-row rig and tried something brand new on about 7/10th of an acre.A historical marker on the roadside now commemorates his feat. However, this farm is anything but stuck in the past. Today, the operation is comprised of 4,000 acres of rented and owned land operated by John and Alexander Young, Harry’s son and grandson.Just like Harry, the two understand that moving ahead with new agronomic ideas is critical to staying in business.John, who was 11 years old when his father tried no-till, said it’s important to keep looking for ways to improve. That’s just good business as well as family tradition.NO-TILL MISSION“My grandfather had a mission. He was enough of a conservationist to see the benefits of no-till. When he started out, he was mainly interested in stopping erosion. It doesn’t take long to erode a field in western Kentucky,” Alexander said. “Then, it became apparent that no-till could save a lot of diesel and manpower.”Harry got the urge to try no-till when Extension agent Reeves Davie took a group of farmers to see University of Illinois agronomist George McKibben’s work at Dixon Springs. Harry, who worked in Kentucky Extension eight years prior to farming full-time, came home prepared to give it a try. Thanks to herbicides like atrazine and 2,4-D, he thought he could control weeds in corn, so that gave him confidence.The technique worked well enough to try it again on more acres. Word spread. Tour groups started rolling onto the Young farm. Harry became a no-till evangelist, speaking at numerous farmer gatherings. His friend, Shirley Phillips, a Kentucky Extension agent who went on to become a state row-crop specialist, became enthused, too, and the two worked in tandem talking up no-till. In 1973, they coauthored a textbook about no-till farming.As with every new idea, there were people who didn’t see the advantages of no-till.“Dad kept going forward with it,” John said. “When he thought he had a good idea, he wouldn’t drop it easily. He thought it would be advantageous for everyday farmers.”Good thing he had that stubborn streak. In 2012, Lloyd Murdock, Kentucky Extension soils specialist, called no-till one of the five top agricultural advances of the past century.ORGANIC MATTER MATTERSThe Young farm continues to use technology to stay economically sustainable. Building soil remains the heart of their program.“As we have continued with no-till, soil organic matter continues to build. We started intensive soil-sampling and recordkeeping in 2008 and have been able to plot a steady increase in organic matter,” Alexander said.“But 10 years is a very limited data set for soil,” he continued. “Organic matter has definitely increased, though. We know it was roughly 1.5% when my dad started farming. Now, it’s up to about 3 to 3.5%.”Their soil varies across the farm from thin, rocky hills to rich bottomland. Average it all, though, and soil quality continues to improve, according to their data.“Our biggest limiting factor here is water-holding capacity. Therefore, rainfall and irrigation are crucial,” Alexander said. “The great thing about higher organic matter is that fields are better able to weather drought. The corn and soybeans have better access to moisture. There are lots of benefits.”They were quick to use variable-rate technology because of their varying soil types. “Variable-rate technology was made for farms like ours,” Alexander explained. “It helps us a lot. There can be quite a difference in soil and topography within 200 feet.”They soil-sample in zones then put those recommendations to work across their fields. “Corn is planted on variable-rate prescriptions based on topography and how steep the ground is, based on soil type,” Alexander said. “Nutrients get applied using variable-rate, too.”EARLY ADOPTERSFifty-six years after Harry Young Jr. tried no-till, his son and grandson remain curious and up-to-date on technology. “My dad has always been a proponent of new technology. So was his dad,” Alexander said.As a teenager, Alexander worked part-time doing IT (information technology) for a hospital. He further honed his computer skills in college, majoring in agricultural science at Murray State University. While working on his agricultural economics and statistics master’s degree at the University of Tennessee, he learned GIS (geographic information systems) technology, which is applied on the farm.“I always wanted to come back to farm and rented farmland when I was still in school,” Alexander said. “Family is important to us, and keeping this farm viable and productive for future generations is important. We treat rented land the same as we do our owned land.”Now 36, one of five siblings including a brother with a Ph.D. in ag economics from Purdue University, Alexander expects to raise his own family right here. He doesn’t expect huge financial rewards and even drives a pickup truck with nearly 500,000 miles on it.A sixth-generation farmer in Christian County, where the family first grew crops in the 1830s, Alexander said the tradition may carry on right within his own household. He and his wife are raising four children.That’s the real reward for Alexander. Being on a farm that’s part of agricultural history is nice, but staying current with technology to carry it forward for future generations is even better.(ES/SK )© Copyright 2019 DTN/The Progressive Farmer. All rights reserved.
Arellano University kept its playoff hopes alive in the Filoil Flying V Preseason Premier Cup after dealing Mapua its seventh straight loss, 68-58, Wednesday in the group stages at the tournament’s namesake arena in San Juan.The Chiefs improved to 3-4 in Group B putting them at sixth place while the Cardinals are yet to win a match with a miserable 0-7 record.ADVERTISEMENT After starting 0-4, Jerry Codiñera’s group has went on to win three straight and the Arellano head coach said they’ve been adjusting to the exit of former superstar Jio Jalalon who now plays in the PBA.“We’re the second-best team last year here in Filoil, and we’re still feeling the loss of Jio,” said Codiñera. “The team had an imbalance and we’re just hoping that the ones left behind can carry the team.”FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSMalditas save PH from shutoutArellano shot poorly from the floor, 25-of-81, for a dismal 31 percent but the Chiefs had it covered grabbing 21 offensive rebounds.Kent Salado had 17 points and six rebounds to lead Arellano while Lervin Flores had a 10-point, 20-rebound double-double. Cayetano dares Lacson, Drilon to take lie-detector test: Wala akong kinita sa SEA Games Lacson: SEA Games fund put in foundation like ‘Napoles case’ For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. BREAKING: Cop killed, 11 hurt in Misamis Oriental grenade blast Every 18 seconds someone is diagnosed with HIV Sports Related Videospowered by AdSparcRead Next BSP survey: PH banks see bright horizon amid dark global recession clouds Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Pagasa: Storm intensifies as it nears PAR Palace: Duterte to hear out security execs on alleged China control of NGCP MOST READ WATCH: Kobe Bryant trolls Jalen Rose in ESPN commercial LATEST STORIES Don’t miss out on the latest news and information. BREAKING: Cop killed, 11 hurt in Misamis Oriental grenade blast Cedric Pelayo led Mapua with 13 points and nine rebounds. View comments
MANILA, Philippines—Roselyn Doria knows that it’s best to accept any accolade with class and humility.ADVERTISEMENT Doria finished the season with 0.69 kill blocks per frame for the Lady Bulldogs, who finished the season at no. 6 with a 4-10 record, while the 2nd Best Middle Blocker Maddie Madayag of Ateneo tallied 0.86 kill blocks per set.This did not bode well with some fans.NU’s quiet captain, however, rose through the unwarranted hate and chose to savor the moment.“I’m thankful because I didn’t expect this,” said Doria. “All I could think of was I wasn’t going to win any award as long as I know that I gave my best this season.”ADVERTISEMENT Sports Related Videospowered by AdSparcRead Next Two-day strike in Bicol fails to cripple transport Filipino athletes get grand send-off ahead of SEA Games PLAY LIST 01:27Filipino athletes get grand send-off ahead of SEA Games00:59Sports venues to be ready in time for SEA Games02:24Sotto urges Robredo to accept antidrug post02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss LATEST STORIES National University’s graduating senior was named as the 1st Best Middle Blocker of the UAAP Season 81 women’s volleyball tournament, much to the chagrin of some fans.Doria, however, humbly took the trophy and let the award speak for her worth.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logistics“My parents told me to just be quiet because I didn’t take any part in all that controversy, whatever was given to me then I will accept it,” said Doria in Filipino Wednesday at Mall of Asia Arena.“I won’t entertain what people are saying about me.” Hunger for winning never goes away for Alex Cabagnot Duterte wants probe of SEA Games mess Catholic schools seek legislated pay hike, too ‘Rebel attack’ no cause for concern-PNP, AFP MOST READ DA eyes importing ‘galunggong’ anew View comments Cayetano: Senate, Drilon to be blamed for SEA Games mess Don’t miss out on the latest news and information. Private companies step in to help SEA Games hosting Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue
New Delhi: While the bonhomie between New Delhi and Dhaka remains intact, both neighbours hold divergent views on the contentious issue of ‘illegal immigration’ from Bangladesh.For the first time, Home Minister Amit Shah categorically raised the ‘India’s concern regarding the illegal movement of undocumented persons across the border’ in the recently held bilateral meeting with visiting Home Minister of Bangladesh Asaduzzaman Khan. Without mentioning the ongoing process of the National Register of Citizen (NRC) in Assam, Shah did propose a mechanism ‘ to find a solution to this problem, especially in North-East India. Also Read – India gets first tranche of Swiss bank a/c detailsThe Bangladesh minister with his delegation met PM Modi before leaving for Dhaka on August 8, and went satisfied with the assurance given by the PM on cooperation with Bangladesh. Bangladesh issued a statement saying PM Modi expressed a desire to participate in the centenary birthday celebration of Bangabandhu Sheikh Mujibur Rahman. After a marathon meeting held in North Block, both countries could not arrive at a consensus because Bangladesh is of the view that no such migration is taking place to India after 1971. Finally, the idea of issuing a joint statement was dropped, instead, both countries decided to come out with their individual statements. Also Read – Tourists to be allowed in J&K from ThursdayAfter that Amit Shah had a one-to-one restricted meeting with his Bangladeshi counterpart and later secretary-level meetings went on till late night. Later Bangladesh High Commission issued a statement where the issue of illegal immigration was not mentioned. However, the statement issued by the Union Home Ministry did mention the issue of illegal immigration and the proposals made in the 7th joint meeting between India and Bangladesh. The statement issued by Bangladesh High Commission spoke of Home Minister Amit Shah being invited to Dhaka. It also claimed that both the ministers expressed satisfaction about ongoing cooperation between two countries on the border and they wanted to keep up that momentum. The home ministry statement said that both neighbours agreed on the need for greater cooperation to achieve the aim of a secure border. Despite the different views on illegal immigration Shah reiterated India’s full support for PM S K Hasina’s development agenda. Both the ministers reiterated the significance attached to the bilateral relationship.
Toronto police say a “significant development” is expected today in the case of a neurosurgeon accused of killing his physician wifeMohammed Shamji is charged with first-degree murder in the death of Elana Fric-Shamji, the mother of his three children.Shamji is scheduled to appear at a Toronto courthouse this morning.Jury selection in his case was scheduled to begin this week.Fric-Shamji, a family doctor at Scarborough and Rouge Hospital, was last seen Nov. 30, 2016.Her beaten body was found in a suitcase by the side of a road north of Toronto the following day.Shamji, her husband of 12 years, was arrested a day later. The Canadian Press
Facebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsAppNASSAU, Bahamas – November 8, 2017 – ‘An Honorable man’ said the Minister of Works as he tabled the reports from Ernst&Young on Wednesday in the House of Assembly, which alleged that the former Minister responsible was somehow less than that.Minister Desmond Bannister’s remarks refuted media reports of the audio report that Opposition Leader, Philip Davis abused his power as the then Minister of BEC, now BPL while being the Deputy Prime Minister and Minister of Works of The Bahamas.Speaking was the current Minister of Works, Desmond Bannister who said, “…Mr. Speaker, the report makes an allegation in relation to the leader of the opposition. I wish to confirm that the allegation is incorrect. It is based on incomplete records at BPL, and I wish to say unequivocally that there is no evidence whatsoever that the leader of the opposition did anything wrong.”The former Chairman of BEC, Leslie Miller had said much the same when contacted about the allegation in the forensic audit; that he did not know of any contracts being awarded to Mario’s Bowling Alley which he owns or to the brother the former DPM, Brave Davis while the two headed the organization. Miller said contracts usually went to the lowest bidder.The audit said at least 19 contracts were awarded without the proper processing to members of the Board and public officials. But Minister Bannister added in his remarks in the House yesterday that, “Sir, I wish to table Volumes 1 and 2 of the report together with a letter from Permanent Secretary Higgs which completely exonerates the leader of the opposition. I know him to be an honourable man, and would not wish to see his reputation besmirched.” Bahamas Power company cuts electricity ahead of Hurricane Irma; storm changes direction. Bahamas: Current PLP Leader and former PLP MP implicated in ‘shady’ contract awards, Miller denies the audit Recommended for you Bahamas ‘Brave Davis’ wants to be Prime Minister and DNA gets new leader, ‘Bran’ steps down Related Items:#BEC, #BPL, #desmondbanniser, #ernst&young, #PhilipDavis